Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.
نویسندگان
چکیده
N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The binding mode was characterised by crystallography and provides a structural rationale for selectivity.
منابع مشابه
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase† †Electronic supplementary information (ESI) available. The coordinates and structure factor files have been deposited in the Protein Data Bank under the accession codes 5A27 and 5A28. See DOI: 10.1039/c5md00241a Click here for additional data file.
donovani N-myristoyltransferase Mark D. Rackham,1,∞, §Zhiyong Yu,1,∞,§ James A. Brannigan,2 William P. Heal,1,∞ Daniel Paape,3,∞ K. Victoria Barker,1,∞ Anthony J. Wilkinson,2 Deborah F. Smith,3 Robin J. Leatherbarrow, 1,∞ and Edward W. Tate1* 1 Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K. 2 Structural Biology Laboratory, Department of Chemistr...
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عنوان ژورنال:
- MedChemComm
دوره 6 10 شماره
صفحات -
تاریخ انتشار 2015